Thomas Barker headshot
TB

Tom Barker

Professor
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR5, 1229
409 Lane Rd
Charlottesville, Virginia 22903
Education
B.S. ​Oglethorpe University, 1995
M.S. ​University of Alabama at Birmingham, 1999
Ph.D. ​University of Alabama at Birmingham, 2003
Post-Doc ​University of Washington and the Hope Heart Institute, 2003-2004 and Ecole Polytechnique Federale de Lausanne, 2004-2006
Biography

Dr. Barker is a Professor in Biomedical Engineering in the Schools of Engineering and Medicine at the University of Virginia. He performed his academic and scientific training with Drs. James Hagood, Joanne Murhpy-Ullrich, Helene Sage, and Jeffrey Hubbell prior to his first faculty post at Georgia Institute of Technology, where he spend 10 years as an Assistant and Associate Professor. Dr. Barker’s research integrates engineering and quantitative approaches with basic cell and molecular biology to understand and control cell phenotype through their interactions with natural and engineered extracellular matrices. Dr. Barker is also focused on understanding the fundamental roles of cell mechanotransduction and mechanical forces in regulating the biochemical activity of proteins in the extracellular matrix toward wound repair, regeneration, and fibrosis. Dr. Barker has established a number of fundamental systems based on rational mutagenesis, molecular evolution of extracellular matrix protein fragments and antibodies that allow both basic biochemical and cell biological studies on the ECM and detection and treatment of organ fibrosis. Dr. Barker has co-authored research and review papers in leading cell biology, matrix biology, and biomaterials journals, he received the NIH Director’s Transformative Research Award in 2015. Dr. Barker was also the recipient of the American Society for Matrix Biology’s Young Investigator Award in 2012 and Iozzo Award in 2016.

EN-BME Platelet-like particles for augmenting hemostasis
Source: U.S. NIH Heart, Lung, And Blood Institute
July 01, 2016 – December 31, 2021
EN-BME Mechanosensors that detect and treat Lung Fibrosis
Source: U.S. NIH Heart, Lung, And Blood Institute
August 04, 2016 – June 30, 2021
American Society for Matrix Biology 2019 Workshop on Fibroblasts: The Arbiters of Matrix Remodeling
Source: U.S. NIH Heart, Lung, And Blood Institute
June 21, 2019 – May 31, 2021
Inflammatory Cytokines Promotes Pro-Fibrotic Thy-1 Negative Fibroblast Subpopulations in Lung Fibrosis-Fellowship on behalf of Daniel Abebayehu
Source: U.S. NIH Heart, Lung, And Blood Institute
May 01, 2019 – April 30, 2021
EN-BME Development of Platelet-Like Particles for Augmentation of Hemostasis in Congenital Heart Defect Patients at High Risk for Bleeding During Cardiac Surgery
Source: U.S. DOD - Army - Medical Research Acquisition Act
November 21, 2016 – November 29, 2020
EN-BME Targeting the Alpha v integrin mechanotransfunction axis in IPF
Source: U.S. NIH Heart, Lung, And Blood Institute
September 01, 2016 – March 31, 2020
NIST--Undergraduate Research Fellowship Gaithersburg, MD
Source: National Institute of Standards & Technology
May 01, 2018 – September 30, 2018
BME 2104: Cell and Molecular Biology for Engineers
Credits: 3
Introduces the fundamentals of cell structure and function, emphasizing the techniques and technologies available for the study of cell biology. A problem-based approach is used to motivate each topic. Divided into three general sections: cell structure and function includes cell chemistry, organelles, enzymes, membranes, membrane transport, intracellular compartments and adhesion structures; energy flow in cells concentrates on the pathways of glycolysis and aerobic respiration; information flow in cells focuses on modern molecular biology and genetic engineering, and includes DNA replication, the cell cycle, gene expression, gene regulation, and protein synthesis. Also presents specific cell functions, including movement, the cytoskeleton and signal transduction. Prerequisite: CHEM 1610 or instructor permission.
BME 3030: Design and Innovation in Medicine
Credits: 3
A project-based grounding in biomedical product design, with emphasis on clinical immersion and topics including design fundamentals, problem/needs identification, delineation of realistic constraints and product specifications, intellectual property, market analysis, entrepreneurship, specific advanced design topics, business plan development, venture funding, and medical product testing methods.REQ: instructor permission .
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
BME 6030: Design and Innovation in Medicine
Credits: 3
A project-based grounding in biomedical product design, with emphasis on clinical immersion and topics including design fundamentals, problem/needs identification, delineation of realistic constraints and product specifications, intellectual property, market analysis, entrepreneurship, specific advanced design topics, business plan development, venture funding, and medical product testing methods. Prerequisite: Instructor Permission
BME 8999: Master's Research
Credits: 1–12
Master's Research
BME 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.

NASA Space Fellow, GSRP, Division of Physical and Biological Sciences, NASA HQ 2002

Ruth L. Kirschstein Postdoctoral Fellow, NIGMS 2004

Walter A. Rosenblith New Investigator Award, Health Effects Institute 2008

American Society for Matrix Biology, Young Investigator Award 2012

NIH Director’s Transformative Research Award 2015

American Society for Matrix Biology, Iozzo Award 2016

College of Fellows, American Institute of Medical and Biological Engineering 2017