Nathan Swami headshot
NS

Nathan Swami

Professor
Unit: School of Engineering and Applied Science
Department: Department of Electrical and Computer Engineering
Office location and address
Wilsdorf Hall B003-B009
351 McCormick Rd
Charlottesville, Virginia 22903
Education
B.S. ​Indian Institute of Technology, Banaras Hindu University, Varanasi, India, 1991
M.S. ​University of British Columbia, Vancouver, 1993
Ph.D. ​University of Southern California, Los Angeles, 1998
Post-Doc Senior Scientist at Clinical MicroSensors Inc, a Caltech start-up focused on DNA sensors, 1999-2000 and Principal Scientist at Motorola Labs, MEMS & Microfluidics 2000-2003
Biography

Nathan Swami is an Associate Professor of Electrical & Computer Engineering at the University of Virginia (UVA), Charlottesville, VA. His group seeks to develop electrically functional microfluidic devices and instrumentation for label-free manipulation, sorting and cytometry of biosystems, for applications in biomolecular sensing, in vitro disease modeling and integrative tissue regeneration. Some of the chief enablers in his group include: (1) soft imprint lithography for 3D patterning of biodegradable scaffolds towards patterning cellular interactions for enabling tissue regeneration; (2) electrochemical analysis in microfluidic and droplet systems for biomolecular sensing; and (3) label-free impedance and deformability-based sorting and cytometry of biosystems. Prior to University of Virginia, he served on the scientific staff of the MEMS & Microfluidics group at Motorola Labs and prior to that, he served as a Scientist at Clinical Microsensors, Inc., a Caltech start-up interfacing microelectronics to bio-analysis. He seeks to impact emerging biomanufacturing approaches, as well as detection systems within point-of-care and resource-poor settings for personalizing medical decisions.

Biofabricated nanoconfined materials and devices for bio-recognition and sensing
Source: Asian Office of Aerospace R&D
September 30, 2021 – September 29, 2024
On-chip integration of sample preparation and monitoring with dielectrophoretic cell isolation
Source: CytoRecovery, Inc.
March 15, 2021 – February 28, 2022
Prognostic selection of osteogenic stem cells using label-free microfluidic separation
Source: U.S. DOD - Army - Medical Research Acquisition Act
February 01, 2020 – January 31, 2022
MD-CANC Cancer Center Support Grant
Source: U.S. NIH Cancer Institute
February 01, 2017 – January 31, 2022
Microsystem for label-free separation and recovery of tumor-associated cells from biopsies for precision medicine
Source: Virginia Polytechnic Institute and State Universit
January 01, 2020 – December 31, 2021
AS-CHEM Completion of the SONIC DE System for Implementation in Forensic Laboratories
Source: U.S. Department Of Justice
January 01, 2020 – December 31, 2021
Nano-Inspired Biosensors for Sleep Apnea
Source: Cambridge Medical Technologies
January 01, 2020 – December 31, 2021
Nano-confinement based platforms for screening bio-recognition elements and multiplexed sensing
Source: Asian Office of Aerospace R&D
September 01, 2018 – August 31, 2021
MD-MICR Exploring the Role of Mitochondrial Fission in Pancreatic Tumoringenisis
Source: U.S. NIH Cancer Institute
July 01, 2016 – June 30, 2021
Development of a platform for label-free high-throughput single-cell authentication of induced-pluripotent stem cell derived transplants
Source: Advanced Regenerative Manufacturing Institute, Inc
July 01, 2019 – January 26, 2021
EN-EE Optimizing Inter-Microbial Antagonisms to Control Clostridium Difficile Infection
Source: U.S. NIH Institute of Allergy & Infectious Disease
January 20, 2017 – December 31, 2019
Microfluidic fabrication and power amplifier systems for contactless dielectrophoresis
Source: CytoRecovery, Inc.
November 01, 2018 – October 31, 2019
EN-EE 15IOA105 - Aptamer-Based Nano-Slit Platforms for Characterizing Human Performance Biomarkers
Source: Asian Office of Aerospace R&D
September 24, 2015 – November 23, 2018
Aptamer-Based Multiplexed Target Detection Platform for Quantifying Human Performance
Source: UES, Inc.
July 01, 2017 – October 16, 2018
AS-CHEMThe FaSTR LL-30 DNA Profiling System: An Ultrarapid, Centrifugally-driven Microfluidic System for Limited Loci STR deoxyribonucleic acid (DNA) Profiling: Phase 3
Source: Naval Air Warfare Center
March 31, 2017 – July 25, 2018
AS-CHEM JPL The FaSTR LL-30 DNA Profiling System: An Ultrarapid, Centrifugally-Driven Microfluidic System
Source: Naval Air Warfare Center
December 02, 2015 – December 31, 2017
EN-EE Electrically Mediated Complex Tissue Regeneration
Source: University Of Connecticut
August 01, 2013 – July 31, 2017
EN-EE PhenoCHIP: Phenotype-Based Cell Hierarchy and Isolation Platform
Source: Virginia Polytechnic Institute and State Universit
January 01, 2014 – December 31, 2015
EN-EE AFRL Collaboration to Investigate Aptamer-Based Electrochemical Detection of Cortisol and Neuropeptide Y in Microfluidic Devices
Source: UES, Inc.
December 31, 2014 – December 30, 2015
EN-EE Nanofluidic Devices for Monitoring Human Performance Biomarkers
Source: Asian Office of Aerospace R&D
June 03, 2014 – December 02, 2015
AS-CHEM JPL The FaSTR LL-30 DNA Profiling System: An Ultrarapid, Centrifugally-Driven Microfluidic System
Source: Naval Air Warfare Center
December 02, 2014 – December 01, 2015
Nanofluidic Pre-Concentration Devices for Enhancing the Detection Sensitivity and Selectivity of Biomarkers for Human Performance Monitoring
Source: Asian Office of Aerospace R&D
August 09, 2011 – February 08, 2015
EN-ECE Nanofluidic Devices for Electrokinetic Enrichment & Separation to Neuropeptide Biomarkers
Source: UES, Inc.
April 22, 2013 – January 15, 2014
Interconnecting Molecular Devices with Patterned Polymeric Contact Layers
Source: U.S. NSF - Directorate For Engineering
June 01, 2007 – May 31, 2013
EN-ECE Biological, Chemical and Mechnical Surface Cues for Cell Migration, Proliferation and Differentiation
Source: University Of Connecticut
January 01, 2012 – April 30, 2013
ENGR 3610: Nanoscale Devices & Systems
Credits: 3
The ability to spatially localize, pattern and interconnect structures with nanoscale resolution is critical for emerging technologies. This course utilizes a hierarchical approach to survey nanotechnologies, beginning with the emerging phenomena at the nanoscale; their device application for electronics, photonics, biosensing and tissue regeneration; the fabrication of integrated nanosystems; and finally their impacts on environmental systems. Prerequisite: APMA 2130, and SEAS-required physics and chemistry courses.
ECE 4155: Microelectronic Integrated Circuit Fabrication Laboratory
Credits: 2
Fabrication and testing of MOS capacitors. Determination of material properties, including carrier concentration, mobility, lifetime, orientation, and layer thickness. Device fabrication using oxidation, diffusion, evaporation, and device testing of MOS and power bipolar transistors. Corequisite: ECE 5150.
ECE 4907: Electrical Engineering Projects
Credits: 1–3
Under faculty supervision, students plan a project of at least one semester's duration, conduct the analysis or design and test, and report on the results. If this work is to be the basis for an undergraduate thesis, the course should be taken no later than the seventh semester. Prerequisite: Instructor permission.
ECE 4908: Electrical Engineering Projects
Credits: 1–3
Under faculty supervision, students plan a project of at least one semester's duration, conduct the analysis or design and test, and report on the results. If this work is to be the basis for an undergraduate thesis, the course should be taken no later than the seventh semester. Prerequisite: Instructor permission.
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
ECE 5150: Microelectronic Integrated Circuit Fabrication
Credits: 3
Explores fabrication technologies for the manufacture of integrated circuits and microsystems. Emphasizes processes used for monolithic silicon-based systems and basic technologies for compound material devices. Topics include crystal properties and growth, Miller indices, Czochralski growth, impurity diffusion, concentration profiles, silicon oxidation, oxide growth kinetics, local oxidation, ion implantation, crystal annealing, photolithography and pattern transfer, wet and dry etching processes, anisotropic etches, plasma etching, reactive ion etching, plasma ashing, chemical vapor deposition and epitaxy; evaporation, sputtering, thin film evaluation, chemical-mechanical polishing, multilevel metal, device contacts, rapid thermal annealing, trench isolation, process integration, and wafer yield. Prerequisite: ECE 3103 or equivalent.
CHEM 5760: Bioanalytical Microsystems
Credits: 3
Presents the analytical and physical science opportunities from the study of biosystems in engineered microsystems
ECE 6155: Microelectronic Integrated Circuit Fabrication Laboratory
Credits: 2
Topics include the determination of semiconductor material parameters: crystal orientation, type, resistivity, layer thickness, and majority carrier concentration; silicon device fabrication and analysis techniques: thermal oxidation, oxide masking, solid state diffusion of intentional impurities, metal electrode evaporation, layer thickness determination by surface profiling and optical interferometer; MOS transistor design and fabrication using the above techniques, characterization, and verification of design models used. Corequisite: ECE 5150.
ECE 6993: Independent Study
Credits: 1–3
Detailed study of graduate course material on an independent basis under the guidance of a faculty member.
ECE 6995: Supervised Project Research
Credits: 3–6
Formal record of student commitment to project research under the guidance of a faculty advisor. A project report is required at the completion of each semester. May be repeated as necessary.
ECE 7993: Independent Study
Credits: 3
Detailed study of graduate course material on an independent basis under the guidance of a faculty member.
ECE 7995: Supervised Project Research
Credits: 3–6
Formal record of student commitment to project research under the guidance of a faculty advisor. Registration may be repeated as necessary.
ECE 8897: Graduate Teaching Instruction
Credits: 1–12
For master's students.
ECE 8999: Thesis
Credits: 1–12
Formal record of student commitment to master's thesis research under the guidance of a faculty advisor. May be repeated as necessary.
CHEM 9760: Research in Bioanalytical Microsystems
Credits: 1–12
Students will conduct research in bioanalytical microsystems using appropriate instrumentation and techniques.
ECE 9897: Graduate Teaching Instruction
Credits: 1–12
For doctoral students.
ECE 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.