Mark Shaffrey headshot

Mark E. Shaffrey

Chair, Neurosurgery
Unit: School of Medicine
Department: Department of Neurological Surgery
Office location and address
101 Hospital Dr
Charlottesville, Virginia 22903
M.D., University of Virginia, 1987
Resident, Neurosurgery, University of Virginia
Fellow, Neuropathology and Microvascular, University of Virginia

Mark Edwin Shaffrey, MD, is a professor of neurosurgery and chair of the Department of Neurosurgery at the University of Virginia. He has won numerous awards for laboratory investigation and clinical medicine, including a traveling fellowship from the Royal College of Surgeons, and has been named to the Best Doctors in America list.

Dr. Shaffrey graduated magna cum laude from Virginia Tech and received his medical degree from the University of Virginia, where he was elected to the Alpha Omega Alpha honor society. He completed his general surgical internship at Wilford Hall USAF Medical Center and his neurosurgical training at the University of Virginia in 1994. During residency, he completed a clinical neuropathology fellowship and an NIH postdoctoral fellowship in microvascular physiology. He also trained as a skull base surgery fellow in Ljubljana, Slovenia, and served as a neurosurgical registrar in Plymouth, England.  

Following his postgraduate training, Dr. Shaffrey served as chief of neurosurgery at Keesler USAF Medical Center, and was decorated with the Meritorious Service Medal. In 1997, he returned to the University of Virginia as an associate professor of neurosurgery and founded the Neuro-Oncology Center. He was appointed chair of the Department of Neurosurgery in 2006.

Dr. Shaffrey’s research interests in neuro-oncology include the molecular mechanisms of cellular invasion and migration. He has approximately 100 publications and has been a funded principal investigator in over 40 grants and clinical trials. He serves on the editorial board and as topic editor for the Self-Assessment in Neurological Surgery (SANS). He is also a reviewer for the Journal of Neurosurgery, Neurosurgery, Surgical Neurology, and Cancer.  

In addition, Dr. Shaffrey plays an active role in organized neurosurgery, having served in several roles for the Congress of Neurological Surgeons and the American Association of Neurological Surgeons.

Source: Medtronic Sofamor Danek
September 04, 2017 – September 03, 2022
Effectiveness of Fusion for Grade I Spondylolisthesis Study
Source: NeuroPoint Alliance
July 01, 2017 – June 30, 2020
MD-SURG CALLAND Rwanda Ministry of Health/US Academic Consortium Human Resources for Health
Source: Republic of Rwanda, Minister of Health
July 01, 2012 – June 30, 2020
Source: Focused Ultrasound Foundation
July 01, 2017 – June 30, 2019
AANS 2018 New Orleans
Source: Medtronic Inc.
January 01, 2018 – May 15, 2018
MD-NERS Nuvasive Res Edu 2016
Source: NuVasive, Inc.
December 01, 2015 – April 30, 2017
MD-NERS Post-Approval Study: Prestige LP Cervical Disc - 10 Year Visit - PI Mark Shaffrey
Source: Medtronic Sofamor Danek
March 15, 2015 – March 15, 2017
MD-NERS DuraSeal Exact Spine Sealant System Post-Approval Study
Source: Integra LifeSciences Corporation
April 30, 2014 – January 30, 2017
MD-NERS CNS 2013 Depuy
Source: DePuy Spine, Inc.
July 15, 2013 – December 31, 2013
MD-NERS HyperBranch
Source: HyperBranch Medical Technology, Inc.
August 16, 2010 – August 16, 2013
Efficacy & Safety of Progesterone in Patients with Severe Traumatic Brain Injury
Source: BHR Pharma, LLC
November 29, 2010 – June 30, 2013

  • 2011-2018 Best Doctors in America® List
  • 2015 One of America's Top Cancer Doctors, Newsweek®