Marc Breton headshot
MB

Marc D. Breton

Associate Professor
Unit: School of Medicine
Department: Department of Psychiatry and NB Sciences
Office location and address
560 Ray C. Hunt Dr
Charlottesville, Virginia 22903
Biography

Dr. Marc Breton’s research is centered on bringing engineering techniques such as mathematical modeling, simulation, signal processing and automatic control into the field of medicine and clinical practice. Dr. Breton has participated in the design of the first (and to date only) simulation environment accepted by the US Food & Drugs Administration as replacement for animal studies in pre-clinical assessment of insulin treatment strategies, and is now in charge of its update and further development. He has been principal investigator on many clinical trials aimed at testing new insulin delivery strategies capable of avoiding hypoglycemia and reducing hyperglycemia, using continuous glucose monitors and subcutaneous insulin injection (Artificial Pancreas), and participated to the protocol and system designs.  Aside from his responsibilities in the center Dr Breton enjoys rugby, sailing, food and wine, and family time.

DexCom Master Research Agreement
Source: DexCom, Inc.
August 18, 2020 – August 17, 2025
Adapting Diabetes Treatment Expert Systems to Patient¿s Expectations and Psychobehavioral Characteristics in Type 1 Diabetes
Source: U.S. NIH Institute of Diabetes & Digestive & Kidne
April 01, 2019 – January 31, 2024
In-Silico Validation of AT247 insulin in UVA Automated Insulin Delivery Systems
Source: ARECOR LIMITED
October 26, 2020 – October 25, 2021
Artificial pancreas with unannounced meals: a model-based control approach using eating pattern characterization
Source: American Diabetes Association
January 01, 2019 – June 30, 2021
Web-based simulation tool for self-management support in type 1 diabetes
Source: Juvenile Diabetes Research Foundation Internatl.
March 01, 2019 – February 28, 2021
MD-PSYCH A Study of t:slim X2 with Control-IQ Technology
Source: Tandem Diabetes Care, Inc.
February 18, 2019 – February 17, 2021
MD-PSYCH Improving closed loop control in T1D by combining first principles and data driven glycemic predictions
Source: Juvenile Diabetes Research Foundation Internatl.
July 01, 2019 – December 31, 2020
Validation of a physiological model describing the glucose diffusion from plasma to the interstitial tissue
Source: American Diabetes Association
January 01, 2020 – December 31, 2020
Investigating Blood Glucose Variability and Insulin Action during Menstrual Cycle in Females with Type 1 Diabetes to Design Innovative Therapies
Source: Yale University
January 01, 2020 – November 30, 2020
MD-PSYCH Do-It-Yourself Artificial Pancreas: Improving Understanding of Factors Driving Choice and Uptake of Open Source Systems
Source: Juvenile Diabetes Research Foundation Internatl.
August 01, 2019 – August 14, 2020
MD-PSCH MD-PSYCH Improving Post-prandial Blood Glucose Control with Afrezza during Closedloop Therapy
Source: Yale University
November 01, 2017 – February 28, 2020
In Silico Assessment of Efficacy and Safety of Evening Versus Morning Administration of Iglarlix
Source: Sanofi US Service Inc.
December 21, 2017 – December 31, 2019
Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
Source: Tandem Diabetes Care, Inc.
January 10, 2019 – December 31, 2019
MD-PSCH MD-PSYCH Improving Post-prandial Blood Glucose
Source: Yale University
May 01, 2019 – October 31, 2019
In-Silico Validation of insulin meal bolus methodologies
Source: Sanofi-Aventis Deutschland GmbH
September 04, 2018 – September 03, 2019
MD-PSCH T1D Behavioral Simulator for Decision Support Tool In-Silico Validation
Source: Juvenile Diabetes Research Foundation Internatl.
August 01, 2016 – July 31, 2019
MD-PSYCH Models, signals, and distributed bio-behavioral control of exercise in diabetes
Source: U.S. NIH Institute of Diabetes & Digestive & Kidne
August 01, 2015 – July 31, 2019
MD-PSCH MD-PSYCH Improving Post-prandial Blood Glucose Control with Afrezza during Closed-loop Therapy
Source: Yale University
November 01, 2016 – May 31, 2019
MD-PSYCH CGM-Based Insulin Sensitivity Estimation to Improve Insulin Dosing in Type 1 Diabetes
Source: Juvenile Diabetes Research Foundation Internatl.
April 01, 2017 – March 31, 2019
Improving the Accuracy of the Eversence CGM System
Source: Senseonics, Incorporated
October 16, 2017 – October 15, 2018
Biobehavioral Triggers, Mechanisms, and Control of Glucose Variability in T1DM
Source: U.S. NIH Institute of Diabetes & Digestive & Kidne
September 25, 2012 – June 30, 2017
MD-PSCH In-Silico Study of the Health and Economic Impact of Blood Glucose Meters Inaccuracy
Source: Roche Diabetes Care GmbH
October 20, 2015 – June 30, 2017
MD-PSYCH Testing and Implementation of ITBA AP control algorithm
Source: Instituto Tecnológico de Buenos Aires
September 01, 2016 – April 30, 2017
MD-PSCH Simulation of BGM Accuracy Impact on CGM Calibration and Clinical Outcomes
Source: Bayer Consumer Care AG
March 31, 2015 – September 30, 2016
MD-PSYC Development of Ambulatory Artificial Pancreas Platform (AAPP)
Source: Juvenile Diabetes Research Foundation Internatl.
March 01, 2014 – February 29, 2016
MD-PSYCH Simulation of BGM Accuracy Impact on Clinical Outcomes and Econometrics
Source: Bayer Consumer Care AG
December 15, 2014 – December 31, 2015
MD-PSYCH Feasibility Study of Closed Loop Control in Adolescents with Type 1 Diabetes Mellitus(T1DM) Using Heart Rate Monitoring as an Exercise Indicator
Source: Virginia Commonwealth University
May 01, 2013 – April 30, 2015
UVA Simulation Core Facility Research Division
Source: Juvenile Diabetes Research Foundation Internatl.
February 01, 2011 – April 30, 2014
MD-PSYCH Characterization of Deviation Patterns in Continuous Glucose Sensors
Source: Echo Therapeutics, Inc.
January 24, 2012 – September 30, 2013
SYS 9999: Dissertation
Credits: 1–12
For doctoral students.
PHYS 9999: PhD Thesis Non-Topical Research
Credits: 1–12
For doctoral dissertation, taken under the supervision of a dissertation director.