KJ
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR5-2225
MR5-2225
Charlottesville,
Virginia
22908
Education
B.S. Johns Hopkins University, 1999
Ph.D. Massachusetts Institute of Technology, 2005
Post-Doc Harvard Medical School, 2005-2008
Ph.D. Massachusetts Institute of Technology, 2005
Post-Doc Harvard Medical School, 2005-2008
Biography
Kevin Janes received his B.S. and B.A. degrees in Biomedical Engineering and Spanish at Johns Hopkins University in 1999. He was a Fulbright Scholar at La Universidad de Santiago de Compostela in Spain before attaining his Ph.D. in Bioengineering at M.I.T. in 2005 under the joint supervision of Douglas Lauffenburger and Michael Yaffe. Dr. Janes completed a postdoctoral fellowship at Harvard Medical School in the Department of Cell Biology with Joan Brugge and began his faculty position at the University of Virginia in 2008. During that time, Dr. Janes was recognized as a Pew Scholar, a Packard Fellow, a Kavli Fellow, and a recipient of the NIH Director’s New Innovator Award. He is currently an Associate Professor in the Department of Biomedical Engineering at the University of Virginia, the Chair of the Tumor Biochemistry and Endocrinology study section at the American Cancer Society, and a member of the Board of Reviewing Editors for Science Signaling.
Publications
Sponsored Awards
A premalignant chronology of cell-state variability in basal-like breast cancer
Source: U.S. NIH Cancer Institute
December 01, 2021 – December 31, 2026
Definition and perturbation of cell-regulatory heterogeneities in solid tumors
Source: U.S. NIH Cancer Institute
September 22, 2021 – August 31, 2026
Fellowship on behalf of Roza Przanowska: Long non-coding RNA heterogeneity in ER+ breast cancer
Source: U.S. NIH Cancer Institute
August 01, 2020 – July 31, 2025
Targeted Sphingolipid Metabolism for Treatment of AML
Source: U.S. NIH Cancer Institute
June 01, 2020 – May 31, 2025
How host cell post-transcriptional regulatory adaptations impact chronic coxsackievirus B3 infection - Fellowship on Behalf of Cameron Griffiths
Source: Human Frontier Science Program
April 01, 2021 – March 31, 2024
Heterogeneous loss of GDF11 tumor suppression in triple-negative breast cancer
Source: U.S. NIH Cancer Institute
January 01, 2018 – December 31, 2022
Virginia Kincaid Cancer Research Fund
Source: Virginia Kincaid Charitable Trust
October 01, 2005 – December 31, 2022
EN-BME Engineering Approaches for SIgnal-Transduction Networks
Source: The David & Lucile Packard Foundation
October 15, 2009 – November 30, 2022
An integrated systems approach for incompletely penetrant onco-phenotypes
Source: U.S. NIH Cancer Institute
September 15, 2017 – July 31, 2022
Single-Cell Misregulation of NRF2 in Basal-like Breast Cancer
Source: U.S. NIH Cancer Institute
July 01, 2017 – May 31, 2020
EN-BME (PQB4) Stochastic Profiling of Functional Single-Cell States within Solid Tumors
Source: U.S. NIH Cancer Institute
June 01, 2015 – May 31, 2020
EN-BME Systems Analysis of Intracellular Signaling Modifications Mediated by Chronic CVB3 Infection of Card
Source: American Heart Association
July 01, 2015 – June 30, 2017
A Single-Cell TGFBR-JUND Dichotomy and its Role in Basal-Like Breast Cancer
Source: American Cancer Society
January 01, 2011 – December 31, 2015
EN-BME Network Control of Cellular Decision Processes
Source: The Pew Charitable Trusts
July 01, 2009 – June 30, 2015
Systems-biology Approaches for Decoding Persistent Coxsackievirus B3 Infection
Source: U.S. NIH Institute of Allergy & Infectious Disease
March 01, 2013 – February 28, 2015
Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein
Source: U.S. NIH Office of the Director
September 30, 2009 – June 30, 2014
Postdoctoral Fellowship on Behalf of C.C. Wang
Source: U.S. DOD - Army - Medical Research Acquisition Act
January 01, 2011 – January 31, 2014
Courses
Credits: 3
Introduces the fundamentals of cell structure and function, emphasizing the techniques and technologies available for the study of cell biology. A problem-based approach is used to motivate each topic. Divided into three general sections: cell structure and function includes cell chemistry, organelles, enzymes, membranes, membrane transport, intracellular compartments and adhesion structures; energy flow in cells concentrates on the pathways of glycolysis and aerobic respiration; information flow in cells focuses on modern molecular biology and genetic engineering, and includes DNA replication, the cell cycle, gene expression, gene regulation, and protein synthesis. Also presents specific cell functions, including movement, the cytoskeleton and signal transduction. Prerequisite: CHEM 1610 or instructor permission.
Credits: 3
This course will provide students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. The course will focus on the interplay between methods and logic, with an emphasis on the themes that emerge repeatedly in quantitative experiments.
Credits: 3
Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. Recent topics include Medical Imaging Systems Theory, BME Advanced Design, BME Electronics Lab, and Systems Biology Modeling and Experimentation. Prerequisite: third- or fourth-year standing and instructor permission.
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
Credits: 3
Provides students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. Focuses on the interplay between methods and logic, with an emphasis on the themes that emerge repeatedly in quantitative experiments. Prerequisites: BME 6101 (or equivalent), SEAS graduate student status, or instructor permission.
Credits: 1–6
FOR M.E. STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prerequisites: Instructor Permission Required.
Credits: 1–12
Master's Research
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.
Credits: 1–12
For doctoral dissertation, taken under the supervision of a dissertation director.