Jeffrey Holmes headshot
JH

Jeffrey W. Holmes

Professor
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR5 2232
415 Lane Rd
Charlottesville, Virginia 22903
Education
B.S. ​The Johns Hopkins University, 1989
​Ph.D. University of California San Diego, 1996
​M.D., University of California San Diego, 1998
Postdoctoral Fellow, Cardiology, University of Freiburg (Germany), 1995-1996 and Developmental Biology and Anatomy, University of South Carolina, 1998-1999
Biography

Jeff Holmes is a Professor of Biomedical Engineering and Medicine at the University of Virginia. He obtained his B.S. in Biomedical Engineering from the Johns Hopkins University in 1989, his Ph.D. in Bioengineering from the University of California, San Diego in 1995, and his M.D. from the University of California, San Diego in 1998. His first faculty position was at Columbia University, where he helped found and build a new Biomedical Engineering department from 1999 to 2007. In 2007, Dr. Holmes moved to the University of Virginia, where he heads the Cardiac Biomechanics Group. His laboratory studies the interactions between mechanics, function, and growth and remodeling in the heart, using a combination of computational and experimental models. His research has been funded by the National Institutes of Health, the National Science Foundation, the American Heart Association, the Whitaker Foundation, the Coulter Foundation, and the Hartwell Foundation. Dr. Holmes was awarded the Y.C. Fung Young Investigator Award in 2005, an American Heart Association Established Investigator Award in 2006, and is a Fellow of the American Heart Association and the American Institute for Medical and Biological Engineering (AIMBE). Dr. Holmes has taught a wide range of undergraduate and graduate courses including Computational BME, Fluid Biomechanics, Cardiac Mechanics, Soft Tissue Mechanics, Advanced Quantitative Physiology, Engineering Physiology, Biomedical Innovation, and Ethics for Biomedical Engineers.

Information Storage and Retrieval in the Cardiac Extracellular Matrix
Source: American Heart Association
October 01, 2017 – September 30, 2021
EN-BME Computational Modeling of Scar Formation After Myocardial Infarction
Source: U.S. NIH Heart, Lung, And Blood Institute
September 01, 2014 – December 31, 2020
EN-BME Multiscale Models of Cardiac Growth, Remodeling and Myocardial Infarction
Source: U.S. NIH Heart, Lung, And Blood Institute
September 15, 2015 – May 31, 2020
Predicting and Modifying Left Ventricle Dilation Following Myocardial Infarction
Source: American Heart Association
July 01, 2017 – January 01, 2019
EN-BME Computational Modeling of Scar Formation and Remodeling in Mechanically Loaded Tissues
Source: U.S. NSF - Directorate For Engineering
September 01, 2013 – August 31, 2018
EN-BME-Multiscale modeling of growth following post-infraction mechanical reinforcement
Source: American Heart Association
July 01, 2016 – June 30, 2018
EN-BME-Support for the 2017 Biomechanics, Bioengineering, and Biotransport Conference (SB3C)
Source: U.S. NSF - Directorate For Engineering
April 15, 2017 – March 31, 2018
EN-BME-2017 Summer Biomechanics, Bioengineering and Biotransport Conference
Source: U.S. NIH Institute of Biomedical Imaging & Bioengi
April 05, 2017 – March 31, 2018
EN-BME Gap Junctional Patterning in the Arrhythmic Heart
Source: Virginia Polytechnic Institute and State Universit
January 01, 2016 – December 31, 2017
EN-BME Hartwell Foundation Fellowship - Witzenburg
Source: The Hartwell Foundation
November 01, 2014 – October 31, 2017
EN-BME Atrial Function and Stress Modification From Posterior Electro-Silencing with PVI
Source: nContact, Inc.
June 01, 2015 – August 31, 2016
EN-BME Multi-Scale Modeling of Cardiac Fibroblast Mechanobiology
Source: American Heart Association - Mid-Atlantic Affiliat
July 01, 2014 – June 30, 2016
EN-BME Predicting and Directing Scar Formation after Myocardial Infarction
Source: American Heart Association - Mid-Atlantic Affiliat
July 01, 2014 – June 30, 2016
EN-BME Novel Drug for Tissue Repair and Regeneration
Source: Virginia Polytechnic Institute and State Universit
December 04, 2013 – March 25, 2016
Anistropic Reinforcement to Improve Post-Infarction LV Function
Source: U.S. NIH Heart, Lung, And Blood Institute
January 01, 2012 – December 31, 2014
Model-Based Design of Wall Motion Measures for 4-Dimensional Cardiac Imaging
Source: U.S. NIH Heart, Lung, And Blood Institute
May 01, 2008 – April 30, 2014
BME 2220: Biomechanics
Credits: 3
Introduction to principles of continuum mechanics of biological tissues and systems. Topics include development of selected fundamental methods and results from statics and strength of materials, continuum mechanics, free-body diagrams, and constitutive equations of biological materials. Properties of blood vessels, heart, bone, cartilage, ligaments, tendons, blood, and other tissues. Mechanical basis and effects of pathology and trauma. Prerequisites: APMA 2130, BME 2101, or permission of instructor
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
BME 8550: Advanced Topics in Biomed Engineering
Credits: 3
Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester.
BME 8995: M.E. Supervised Project Research (M.E. STUDENTS ONLY)
Credits: 1–6
FOR M.E. STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prerequisites: Instructor Permission Required.
BME 8999: Master's Research
Credits: 1–12
Master's Research
PHY 9998: Non-Topical Research, Preparation for Doctoral Research
Credits: 1–12
For doctoral research, taken before a dissertation director has been selected.
BME 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.
PHY 9999: Non-Topical Research
Credits: 1–12
For doctoral dissertation.