Jeh-Ping Liu headshot

Jeh-Ping Liu

Associate Professor
Unit: School of Medicine
Department: Department of Neuroscience
Office location and address
409 Lane Rd
Charlottesville, Virginia 22903
Ph.D., 1993, Columbia University

I am interested in understanding the molecular mechanisms that control the generation of different neuronal types along the anterior-posterior (A-P) axis of the spinal cord, using motor neurons as a model system. Spinal motor neurons in the ventral spinal cord extend axons to innervate peripheral muscle targets originating at equivalent A-P levels during embryonic development. I am studying the functions of the Hox-c cluster genes in order to understand how different motor neurons are generated along the A-P axis and how motor neuron identity affects axonal path finding and target selection. Different Hox-c cluster genes are expressed in distinct but overlapping domains along the A-P axis of the spinal cord. Using chick neural explants in an in vitro culture system, I have demonstrated that both paraxial mesoderm and tissues around Hensen’s node initiate the patterned expression of different Hox-c genes in the spinal cord. The secreted molecules from these tissues that induce this patterning event include Fgf8, Gdf11, and retinoic acid. Currently, I am trying to identify genes acting down-stream of these signaling molecules that are required for patterned Hox-c gene expression. I am also addressing the functions of Hox-c genes in defining motor neuron identity and target selection by mis-expressing or removing Hox-c gene function specifically in the spinal motor neurons using transgenic approaches.

NESC 9998: Non-Topical Research, Preparation for Doctoral Research
Credits: 1–12
For doctoral research, taken before a dissertation director has been selected.
NESC 9999: Non-Topical Research
Credits: 1–12
For doctoral research, under the supervision of a dissertation director.