John Hossack headshot
JH

John A. Hossack

Professor
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR5 Rm 2121
415 Lane Rd
Charlottesville, Virginia 22903
Education
B.S. ​University of Strathclyde, United Kingdom, 1986
Ph.D. ​University of Strathclyde, United Kingdom, 1990
Post-Doc ​E.L. Ginzton Laboratory, Stanford University, Stanford, CA 1990-1992
Biography

Molecular imaging using molecular targeted microbubble-based contrast agents.

Ultrasound provides for single particle (single microbubble) imaging sensitivity. When we can detect a microbubble that has adhered to a selected molecular receptor, we have detected the signature of disease at a molecular level. Thus, we can detect disease at the earliest possible stage. The foremost applications are in cardiovascular disease and cancer. Our laboratory is primarily interested in developing new signal processing methods for detecting the signal associated with a molecular (ligand-receptor) bound microbubble with high sensitivity and high specificity in real-time.

Catheter-based ultrasound imaging and drug delivery.

We are also investigating drug delivery to a blood vessel wall and for improved delivery of clot busting drugs with applications in stroke and deep vein thrombosis (DVT). For this work, we place a transducer and a microbubble source (using a microfluidics approach) on a catheter.

Each of the above projects is supported by an existing, or imminent funding,  NIH R01 4-5 year grant.

We are also pursuing projects in photoacoustics, ultrasound image guided radiation oncology (breast cancer application primarily) and in the use of ultrasound for prevention of ischemia-reperfusion injury.

Biography:

I obtained B.Eng. and Ph.D. degrees in Electrical and Electronic Engineering, University of Strathclyde, UK. Thereafter, I was a Post Doctoral Researcher at Stanford University in the E. L. Ginzton Laboratory for two years. I then worked in industry at Acuson, a leading designer and manufacturer of advanced ultrasound imaging equipment in Mountain View, CA for seven years.  Since 2000, I have been an Associate Professor, then Professor, of Biomedical Engineering, (Electrical and Computer Engineering 2006–) at the University of Virginia.

Thus, I have a background in both the academic and industry setting. Additionally, I have been involved in, to a varying degree, three startup companies. Each of these have been successful.

Accelerated low dose thrombolytic catheter directed therapy for thromboembolism
Source: U.S. NIH Heart, Lung, And Blood Institute
July 01, 2018 – June 30, 2022
EN-BME Ultrasound Targeted Molecular Imaging in Large Arteries to Predict AAA Risk
Source: U.S. NIH Heart, Lung, And Blood Institute
July 21, 2016 – April 30, 2022
Ultrasound molecular imaging of aortic aneurysm using modulated acoustic radiation force
Source: American Heart Association
January 01, 2020 – December 31, 2021
MD-INMD Tailoring Ultrasound Technology to explore mechanisms of actiation of the splenic neuroimmune axis in attenuating acute organ injury
Source: U.S. NIH Institute of Biomedical Imaging & Bioengi
September 30, 2015 – January 31, 2019
A Method for Monitoring in situ Microfluidic Microbubble Production in Catheter-Based Sonothrombolysis Stoke Therapy
Source: American Heart Association
July 01, 2016 – June 30, 2018
Ultrasound Targeted Molecular Imaging in Large Arteries to Diagnose Stroke Risk
Source: U.S. NIH Heart, Lung, And Blood Institute
August 15, 2012 – May 31, 2017
Ultrasound Targeted Molecular Imaging in Large Arteries to Diagnose Stroke Risk
Source: U.S. NIH Heart, Lung, And Blood Institute
August 15, 2012 – May 31, 2016
EN-BME New Molecular Imaging Technology for Safe and Inexpensive Cancer Screening
Source: Center For Innovative Technology
January 06, 2014 – December 31, 2015
EN-BME Ultrasound Catheter for Guiding and Effecting Neointimal Hyperplasia Prevention
Source: Soundpipe, LLC
January 02, 2015 – August 31, 2015
EN-BME-GRP Dual-Function Intravascular Ultrasound & Photoacoustic Imagtin Catheter for In-Flight Prev. Diag. & Mangt of Stroke & Myocard. Infarc.
Source: Virginia Space Grant Consortium
June 01, 2013 – May 31, 2015
AHA Predoctoral Fellowship on Behalf of Ali Haider Dhanaliwala
Source: American Heart Association - Mid-Atlantic Affiliat
July 01, 2012 – June 30, 2014
EN-BME Molecular Targeted, Focused, Ultrasound-Based Delivery of Antrproliferative Drugs
Source: U.S. NIH Heart, Lung, And Blood Institute
August 01, 2008 – May 31, 2014
EN-BME High-Resolution 3D Ultrasound Imaging & Quantification of Murine Cardiac Function
Source: U.S. NIH Institute of Biomedical Imaging & Bioengi
August 01, 2009 – May 31, 2014
EN-BME Red Blood Cells as Ultrasound Contrast and Drug Delivery Agents
Source: Virginia Space Grant Consortium
June 01, 2012 – May 31, 2014
Low-Cost Handheld Medical Device for Neuroaxial Anesthesia Guidance in the Obese
Source: Rivanna Medical LLC
July 10, 2012 – July 09, 2013
BME 3310: Biomedical Systems Analysis and Design
Credits: 3
Presents the analytical tools used to model signals and linear systems. Specific biomedical engineering examples include multicompartment modeling of drug delivery, modeling of dynamic biomechanical systems, and electrical circuit models of excitable cells. Major topics include terminology for signals and systems, convolution, continuous time Fourier transforms, Laplace transforms, electrical circuits with applications to bioinstrumentation and biosystems modeling, and applications of linear system theory. Students cannot receive credit for both this course and ECE 3750. Prerequisite: APMA 2130, CS 1110 or instructor permission.
BME 4783: Medical Imaging Modalities
Credits: 3
An overview of modern medical imaging modalities with regard to the physical basis of image acquisition and methods of image reconstruction. Topics cover the basic engineering and physical principles underlying the major medical imaging modalities: x-ray (plain film, mammography, and computed tomography (CT)), nuclear medicine (positron-emission tomography (PET) and single-photo-emission computed tomography (SPECT)), ultrasound, and magnetic resonance imaging (MRI). Prerequisite: BME 3310 or ECE 3750, or instructor permission.
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
BME 6550: Special Topics in Biomedical Engineering
Credits: 1–3
Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester.
BME 8730: Diagnostic Ultrasound Imaging
Credits: 3
Underlying principles of array based ultrasound imaging. Physics and modeling techniques used in ultrasound transducers. Brief review of ID circuit transducer models. Use of Finite Element techniques in transducer design. Design considerations for 1.5D and 2D arrays will be reviewed. Diffraction and beamforming will be introduced starting from Huygen's principle. FIELD propagation model will form an important part of the class. In depth discussion of various beamforming and imaging issues such as sidelobes, apodization, grating lobes, resolution, contrast, etc. The course addresses attenuation, time-gain-compensation and refraction. Finally, speckle statistics and K-Space techniques will be introduced. Laboratories will involve measuring ultrasound image metrics, examining the effect of various beamforming parameters and simulating these on a computer using Matlab. Prerequisite: instructor permission, BIOM 6310 and BIOM 6311. Preparation: Undergraduate Physics, Electronic circuit analysis, Differential Equations, Fourier and Laplace Transforms, Sampling Theorems.
BME 8995: M.E. Supervised Project Research (M.E. STUDENTS ONLY)
Credits: 1–6
FOR M.E. STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prerequisites: Instructor Permission Required.
BME 8999: Master's Research
Credits: 1–12
Master's Research
BME 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.

Fellow IEEE 2015

Edlich-Henderson UVA Innovator of the Year (one of four) 2016

SoundPipe Therapeutics, Scientific Advisor http://www.sound-pipe.com/