Jayakrishna Ambati headshot

Jayakrishna Ambati

Unit: School of Medicine
Department: Department of Ophthalmology
Office location and address
21 Hospital Dr
Charlottesville, Virginia 22903
Residency, Ophthalmology, University of Rochester
Fellowship, Retina Clinical & Research, Massachusetts Eye & Ear Infirmary
MD, Medicine, SUNY Downstate Medical Center College of Medicine

Jayakrishna Ambati is Professor & Vice Chair for Research of Ophthalmology, founding Director of the Center for Advanced Vision Science, and has joint appointments with the Cardiovascular Research Centerand the Biomedical Sciences Graduate Program's departments of Microbiology, Immunology, and Cancer Biology. His scientific aspirations are to identify the molecular mechanisms underlying the development of AMD, determine the triggers of the angiogenic switch that converts this disease from an atrophic to a neovascular phenotype, and to develop novel therapeutics to prevent and treat this blinding condition. 

He is the first ophthalmologist to win the Doris Duke Distinguished Clinical Scientist AwardBurroughs Wellcome Fund Clinical Scientist Award in Translational Research, the Ellison Medical Foundation Senior Scholar in Aging Award, and the Harrington Discovery Institute Scholar-Innovator Award. He was also elected to The American Society for Clinical Investigation and was the first ophthalmologist to be elected to The Association of American Physicians. He has been elected as a Fellow of the American Association for the Advancement of Science. He also serves on the Editorial Board of Investigative Ophthalmology & Visual Sciences, Ophthalmic Research, and is an Associate Editor of Ophthalmology and of Translational Vision Science & Technology. He won the 2010 ARVO Cogan Award, and his Cogan Lecture was recognized with the 2010 Cless Best of the Best Award. He also won the 2010 Roger H. Johnson Memorial Award for Macular Degeneration Research, and a 2010 Research to Prevent Blindness Senior Scientific Investigator Award. He has been named winner of the 2011 AFER/Pfizer Ophthalmics/Carl Camras Translational Research Award and the 2014 CNIB Chanchlani Global Vision Research Award

In 2014, he received the NIH Director’s Pioneer Award, becoming the first ophthalmologist and the first from an institution in Kentucky, to do so. In 2015, he was elected a Fellow of the National Academy of Inventors.

His wife Kameshwari and he derive the greatest joy from playing with their daughters Meenakshi and Vidya, and exploring TED Talks.

Nlrp3 inflammasome activation in early diabetic retinopathy
Source: U.S. NIH Eye Institute
September 01, 2020 – May 31, 2025
Antigen-independent suppression of ocular angiogenesis via the Fc receptor
Source: U.S. NIH Eye Institute
September 01, 2018 – June 30, 2023
Non-canonical inflammasome in activation in RPE degeneration
Source: U.S. NIH Eye Institute
February 01, 2019 – January 31, 2023
MD-OPHT Form and function of our Janus faced genome
Source: U.S. NIH Institute of General Medical Science
August 01, 2016 – July 31, 2019
MD-OPTH Parallel Genomics: Functional
Source: John Templeton Foundation
December 01, 2016 – March 24, 2019
MD-OPHY Inflammasome Activation in Geographic Atrophy
Source: U.S. NIH Eye Institute
September 01, 2016 – August 31, 2018
MD-OPHT Functional studies of DICER1 and Alu RNA in geographic atrophy
Source: U.S. NIH Eye Institute
October 01, 2016 – January 31, 2018
PATH 9995: Topical Research
Credits: 1–12
Original research on approved problems.
NESC 9998: Non-Topical Research, Preparation for Doctoral Research
Credits: 1–12
For doctoral research, taken before a dissertation director has been selected.
NESC 9999: Non-Topical Research
Credits: 1–12
For doctoral research, under the supervision of a dissertation director.
PATH 9999: Non-Topical Research
Credits: 1–12
Dissertation research credit for students who have completed their advancement to candidacy.