Hong-Ru Chen

Assistant Professor
Unit: School of Medicine
Department: Department of Neuroscience
Office location and address
MR-4, 4022
409 Lane Rd
Charlottesville, Virginia 22903
Trainee, Embryology, Marine Biological Laboratory, MA, USA, 2014
Ph.D., Neurodevelopment, National Yang-Ming University, Taipei, Taiwan, 2015

Dr. Chen's primary research interest is to investigate how neurons and monocyte-derived pathological microglia interact to mediate neural physiology and behavior in various neurological conditions, towards the development of immune-targeted therapies of the disease condition. The diseases that she studies include maternal immune activation, neonatal hypoxia-ischemia (HI), infection-sensitized HI, and neonatal stroke. Her second research interest is the developmental effect of infection-sensitized HI in offspring. This is because Autism Spectrum Disorder (ASD) has diverse etiologies due to complex interactions of genetic, immune, and environmental risk factors, including birth asphyxia/hypoxia-ischemia (HI). To test this idea, she has developed a two-hit model of neurodevelopmental defects by subjecting the offspring of murine maternal immune activation (MIA) under a moderate Rice-Vannucci HI insult to produce autistic-like behaviors and synaptic defects.