George Christ headshot
GC

George Joseph Christ

Professor
Director
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR5 1133
415 Lane Rd
Charlottesville, Virginia 22903
Education
B.S. ​Muhlenberg College, 1982
Ph.D. ​Wake Forest University, 1987
Biography

Dr. Christ is an internationally recognized expert in muscle physiology. He is the Past Chairman of the Division of Systems and Integrative Pharmacology of the American Society of Pharmacology and Experimental Therapeutics (ASPET), and Past President of the North Carolina Tissue Engineering and Regenerative Medicine (NCTERM) group. He was inducted into AIMBE in 2017. He currently serves on the Executive Committee of the Division for Integrative Systems, Translational and Clinical Pharmacology of ASPET. He is also on the Editorial Board of five journals and is an ad-hoc reviewer for 2 dozen others. Dr. Christ has authored more than 215 scientific publications and is co-editor of a book on integrative smooth muscle physiology and another on regenerative pharmacology. Dr. Christ has served on both national and international committees related to his expertise in muscle physiology, and on NIH study sections in the NIDDK, NICHD, NCRR, NAIAD, and NHLBI. He has chaired working groups for both the NIH and the World Health Organization. Dr. Christ is a co-inventor on more than 26 patents (national and international) that are either issued or pending, related to gene therapy for the treatment of human smooth muscle disorders and tissue engineering technologies. Dr. Christ has also been the driving scientific force behind the preclinical studies and IND approvals supporting three Phase I clinical trials for gene therapy for benign human smooth muscle disorders. This technology has been evaluated in 55 patients in the US and 21 overseas. He is also spearheading the multi-institutional development of a tissue engineered muscle repair (TEMR) technology platform for the treatment of Wounded Warriors. An IND submission for a 5 patient first-in-man pilot study is anticipated in 2017 to further develop this technology platform for treatment of cleft lip. That study is funded by DOD and will be conducted at UT-Houston. Another 5 patient pilot study has also been funded by DOD to evaluate a proprietary hydrogel for the treatment of lower extremity volumetric muscle loss injuries to the tibialis anterior muscle at UVA. An IDE application for that indication is also anticipated in 2017 in collaboration with Keranetics LLC (W-S, NC). 

Aligned and electrically conductive collagen scaffolds for guiding innervated muscle-tendon junction repair of volumetric muscle loss injuries
Source: U.S. NIH Institute of Arthritis, Musculoskeletal &
May 01, 2021 – March 31, 2026
Clinical Translation of Advanced Technologies for Muscle and Nerve Regeneration
Source: U.S. DOD - Army - Medical Research Acquisition Act
September 01, 2020 – August 31, 2025
Innovative strategies for neuromuscular regeneration and rehabilitation of volumetric muscle loss (VML) injuries resulting from Polytrauma
Source: U.S. DOD - Army - Medical Research Acquisition Act
August 01, 2018 – October 31, 2022
Modular Biofabrication Platform for Diverse Tissue Engineering Applications
Source: Advanced Regenerative Manufacturing Institute, Inc
October 26, 2018 – January 07, 2022
Smithfield_Novel Regenerative Biomaterials Development Sponsored Research Proposal
Source: Smithfield Biosciences
February 01, 2018 – December 31, 2021
EN-BME ER-12 Skeletal Muscle Preservation in an Ischemic Injury Using Particulate Oxygen-Generating Materials
Source: Wake Forest University Health Sciences
January 01, 2015 – December 31, 2021
EN-BME CF-08 Bioreactors and Biomaterials for Tissue Engineering of Skeletal Muscle
Source: Wake Forest University Health Sciences
January 01, 2015 – December 31, 2021
EN-BME CF-13 Hybrid Muscle-Nerve Tissue Integration System (Muntis) for Functional Restoration of Larger Volumetric Muscle Loss Injuries
Source: Wake Forest University Health Sciences
January 01, 2015 – December 31, 2021
Bioinspired hydrogels for craniofacial muscle regeneration
Source: University of California at San Francisco
January 01, 2019 – December 31, 2021
Tunable Composite Biomaterials for Enhanced Neuromuscular Regeneration of Volumetric Muscle Loss Injuries
Source: U.S. DOD - Army - Medical Research Acquisition Act
September 01, 2018 – November 30, 2021
Biofabrication of Regenerative Musculoskeletal Therapeutics
Source: Old Dominion University Research Foundation
August 01, 2018 – September 30, 2021
Predictive Tools Development for Low Cost Carbon Fiber
Source: U.S. Department of Energy
October 01, 2017 – March 31, 2021
Animal studies to support mode of action (MOA) and safety of KeraGenics Muscle
Source: Keratin Biosciences Inc.
September 07, 2018 – May 06, 2020
EN-BME Spatiotemporally Controlled Keratin Biomaterial Delivery System for Functional Tissue Regeneration
Source: Keratin Biosciences Inc.
September 01, 2015 – January 15, 2020
EN-BME Novel Approaches to Tissue Engineered Muscle Repair and Regeneration for Treatment of Volumetric Muscle Loss Injuries
Source: U.S. DOD - Army - Medical Research Acquisition Act
March 15, 2015 – March 14, 2018
EN-BIOM Functional testing of new keratin implant for bioequivalence
Source: Keratin Biosciences Inc.
July 01, 2016 – May 31, 2017
EN-BME Storage Lesion in Banked Blood Due to Disruption of Nitrix Oxide in Homeostasis
Source: Wake Forest University
September 01, 2014 – May 31, 2017
EN-BME Effects of Nitric Oxide in Sickle Cell Blood
Source: Wake Forest University
September 08, 2014 – April 30, 2017
EN-BME Tissue Engineered Skeletal Muscle for Craniofacial Reconstruction and Regeneration
Source: U.S. NIH Institute of Dental and Craniofacial Rese
September 08, 2015 – February 28, 2017
BME 2102: Physiology II
Credits: 3
Introduces the physiology of the kidney, salt and water balance, gastrointestinal system, endocrine system, and central nervous system, with reference to diseases and their pathophysiology. Prerequisite: CHEM 1610, PHYS 1425, or instructor permission.
BME 4993: Independent Study
Credits: 1–3
In-depth study of a biomedical engineering area by an individual student in close collaboration with a departmental faculty member. Requires advanced analysis of a specialized topic in biomedical engineering that is not covered by current offerings. Requires faculty contact time and assignments comparable to regular course offerings. Prerequisite: instructor permission.
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
BME 8995: M.E. Supervised Project Research (M.E. STUDENTS ONLY)
Credits: 1–6
FOR M.E. STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prerequisites: Instructor Permission Required.
BME 8999: Master's Research
Credits: 1–12
Master's Research
PATH 9995: Topical Research
Credits: 1–12
Original research on approved problems.
PATH 9999: Non-Topical Research
Credits: 1–12
Dissertation research credit for students who have completed their advancement to candidacy.
BME 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.