David Brenin headshot

David R. Brenin

Unit: School of Medicine
Department: Department of Surgery
Office location and address
Breast Care Center
81 Hospital Dr
Charlottesville, Virginia 22903
New York Medical College, 1990, MD

David Brenin, MD, FACS is chief of breast surgery, co-director of both the UVA Breast Care Program and the High-Risk Breast and Ovarian Cancer Clinic and is an associate professor of surgery at UVA’s School of Medicine. His clinical practice specializes in the treatment of breast cancer, and benign diseases of the breast. Dr. Brenin is a fellowship trained breast surgeon and is an expert on surgical procedures involving the breast including lumpectomy, sentinel node biopsy, axillary dissection, nipple sparing mastectomy and IORT. His primary research interests include focused ultrasound ablation of breast tumors and immunotherapy.

In addition to his clinical functions, Dr. Brenin is the leader of UVA Cancer Center’s weekly multidisciplinary breast conference, chairman of the Commission on Cancer Committee at UVA Cancer Center and member of the Focused Ultrasound Surgery Foundation’s Fellowship Advisory Committee and grant review committee. He serves on the UVA Health System Tumor Registry Advisory Board and UVA Human Immune Therapy Center Committee. Dr. Brenin is also course co-director for the regional continuing medical education conference “Advances in Comprehensive Breast Care and Imaging,” in Charlottesville and is on the planning committee of the UVA Cancer Center educational series.

His professional affiliations include Fellow of the American College of Surgeons, Society of Surgical Oncology, Eastern Cooperative Oncology Group (breast team CORE committee member) and the American Society of Breast Surgeons. 

A native of New York, Dr. Brenin graduated from SUNY Binghamton in 1986. He earned his MD at New York Medical College in 1990 and completed his residency in surgery and fellowships in breast surgery at Northwestern University. Dr. Brenin’s wife, Dr. Christiana Brenin, also treats breast cancer at UVA Cancer Center and earned her medical degree, served her residency and completed her fellowships at the same locations as her husband, David.

Outside the hospital, Dr. Brenin enjoys spending time with his wife and two daughters as well as hiking, skiing, scuba diving, playing with the family dog and maintaining an extraordinary fish tank.

A premalignant chronology of cell-state variability in basal-like breast cancer
Source: U.S. NIH Cancer Institute
December 01, 2021 – December 31, 2026
MD-SURG Treatment of Breast FA Targeted Tissue With HIFU: A Pivotal Multi Center Prospective Trial
Source: Theraclion, S.A.
December 16, 2016 – December 15, 2023
MD-SURG Treatment of Breast Fibroadenoma with High Intensity Focused Ultrasound
Source: Theraclion, S.A.
August 21, 2013 – December 31, 2021
MD-SURG Treatment of Breast Fibroadenoma with High Intensity Focused Ultrasound: A Feasibility Study
Source: Theraclion, S.A.
April 10, 2014 – April 30, 2020
Source: Vanderbilt University, The
November 12, 2012 – November 11, 2016
  • 2014, 2012 Patients' Choice Award  
  • 2014, 2012 Compassionate Doctor Recognition
  • 2013 Castle Connolly's Top Doctors™ 
  • 2017-2018 Best Doctors in America® List