Brian Helmke headshot
BH

Brian P. Helmke

Associate Professor
Unit: School of Engineering and Applied Science
Department: Department of Biomedical Engineering
Office location and address
MR4 1124
409 Lane Rd
Charlottesville, Virginia 22903
Education
B.S.E., Bioengineering, University of Pennsylvania, 1992
B.S.Econ., The Wharton School, University of Pennsylvania, 1992
​​Ph.D., Bioengineering, University of California, San Diego, 1996
Biography

Living cells and tissues adapt to their environment by altering structure, gene and protein expression, and biochemical functions. For example, endothelial cells lining the artery wall at the blood tissue interface experience fluid mechanical forces that vary with time and location along the artery. However, the mechanisms by which cells transduce mechanical stimuli into biochemical signals are not well understood. Our laboratory employs a multidisciplinary biomedical engineering approach to understand the relationship between intracellular mechanics and cell function.

Cytoskeletal Machinery Driving Invasion by the Human Pathogen, Toxoplasma Gondii
Source: Indiana University
January 01, 2018 – December 31, 2018
EN-BME Endothelialization of Endovascular Coils by Manipulation of Clot Density and Hemodynamics
Source: American Heart Association - Mid-Atlantic Affiliat
July 01, 2014 – June 30, 2016
Ciliated Pediatric Endotracheal Tube for Active Prevention of Ventilator-Associated Pneumonia
Source: The Hartwell Foundation
April 01, 2009 – December 31, 2013
BME 1501: Special Topics
Credits: 1
Student led special topic courses which vary by semester
ENGR 1501: Special Topics
Credits: 1
Student led special topic courses which vary by semester.
BME 2101: Physiology I for Engineers
Credits: 3
We learn how excitable tissue, nerves and muscle, and the cardiovascular and respiratory systems function. You will develop an understanding of mechanisms, with an introduction to structure, an emphasis on quantitative analysis, and integration of hormonal and neural regulation and control. Prerequisites: intro courses in biology, chemistry, physics & calculus (BIOL 2010, CHEM 1610, PHYS 1425, APMA 1110 or similar) or instructor permission.
BME 3240: Biotransport
Credits: 3
Biotransport in biological living systems is a fundamental phenomenon important in all aspects of the life cycle. Course will introduce principles and application of fluid and mass transport processes in cell, tissue and organ systems. Topics include, introduction to physiological fluid mechanics in the circulation and tissue, fundamentals of mass transport in biological systems, effects of mass transport and biochemical interactions at the cell and tissue scales, and fluid and mass transport in organs.
BME 4550: Special Topics in Biomedical Engineering
Credits: 3
Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. Recent topics include Medical Imaging Systems Theory, BME Advanced Design, BME Electronics Lab, and Systems Biology Modeling and Experimentation. Prerequisite: third- or fourth-year standing and instructor permission.
ECE 4641: Bioelectricity
Credits: 3
Studies the biophysical mechanisms governing production and transmission of bioelectric signals, measurement of these signals and their analysis in basic and clinical electrophysiology. Introduces the principles of design and operation of therapeutic medical devises used in the cardiovascular and nervous systems. Includes membrane potential, action potentials, channels and synaptic transmission, electrodes, electrocardiography, pacemakers, defibrillators, and neural assist devices. Cross-listed as BIOM 4641. Prerequisite: ECE 2630, BIOM 2101, or instructor permission.
BME 4995: Biomedical Engineering Advanced Projects
Credits: 1–3
A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission.
KINE 5495: Human Physiology
Credits: 3
As exercise scientists, can we analyze systems in the human body & design strategies to improve quality of life? Our study of physiology aims to explain the physical & chemical mechanisms that regulate the body. These mechanisms maintain homeostasis, relatively constant conditions that are compatible with life. This semester we begin speaking the language of physiology to communicate effectively with clinicians, medical staff & other scientists.
BME 6102: Engineering Physiology II
Credits: 3
Second part of physiology sequence for engineering students; focuses on physiology of the cardiovascular, pulmonary, renal, and nervous systems; emphasizes quantitative analysis of organ function, particularly the use of mathematical models to identify and understand key underlying mechanisms. Prerequisite: BME 6101
BME 7641: Bioelectricity
Credits: 3
Studies the biophysical mechanisms governing production and transmission of bioelectric signals, measurement of these signals and their analysis in basic and clinical electrophysiology. Introduces the principles of design and operation of therapeutic medical devices used in the cardiovascular and nervous systems. Prerequisite: BME 6310 or instructor permission.
BME 8995: M.E. Supervised Project Research (M.E. STUDENTS ONLY)
Credits: 1–6
FOR M.E. STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prerequisites: Instructor Permission Required.
BME 8999: Master's Research
Credits: 1–12
Master's Research
BME 9999: Dissertation
Credits: 1–12
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.